Here’s a paper that will provoke a wave of denial in type nerds everywhere. Short version: setting information in hard-to-read fonts, including Comic Sans Italic, led to better retention amongst research subjects because of “disfluency”. When you have to work harder to read it, you remember it better.
Abstract: Previous research has shown that disfluency – the subjective experience of difficulty associated with cognitive operations – leads to deeper processing. Two studies explore the extent to which this deeper processing engendered by disfluency interventions can lead to improved memory performance. Study 1 found that information in hard-to-read fonts was better remembered than easier to read information in a controlled laboratory setting. Study 2 extended this finding to high school classrooms. The results suggest that superficial changes to learning materials could yield significant improvements in educational outcomes.
In the meantime, you can pry this Scala Regular from my cold, dead hands.